eF-site ID 2hty-ABCD
PDB Code 2hty
Chain A, B, C, D

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Title N1 neuraminidase
Classification HYDROLASE
Compound Neuraminidase
Source ORGANISM_SCIENTIFIC: Influenza A virus;
Sequence A:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI
SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP
VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA
VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM
TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF
GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT
KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY
SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS
ISFCGVNSDTVGWSWPDGAELPFTI
B:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI
SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP
VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA
VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM
TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF
GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT
KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY
SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS
ISFCGVNSDTVGWSWPDGAELPFTI
C:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI
SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP
VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA
VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM
TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF
GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT
KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY
SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS
ISFCGVNSDTVGWSWPDGAELPFTI
D:  VKLAGNSSLCPINGWAVYSKDNSIRIGSKGDVFVIREPFI
SCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMSCP
VGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGA
VAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVM
TDGPSNGQASYKIFKMEKGKVVKSVELDAPNYHYEECSCY
PNAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVF
GDNPRPNDGTGSCGPVSSNGAYGVKGFSFKYGNGVWIGRT
KSTNSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGY
SGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSS
ISFCGVNSDTVGWSWPDGAELPFTI
Description


Functional site
1) chain A
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
2) chain B
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
3) chain C
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
4) chain D
residue 151
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI1
5) chain A
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
6) chain B
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
7) chain C
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
8) chain D
residue 406
type ACT_SITE
sequence Y
description Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI2
9) chain A
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
10) chain B
residue 371
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
11) chain C
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
12) chain C
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
13) chain C
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
14) chain C
residue 292
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
15) chain C
residue 371
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
16) chain D
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
17) chain D
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
18) chain D
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
19) chain D
residue 292
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
20) chain A
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
21) chain D
residue 371
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
22) chain A
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
23) chain A
residue 292
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
24) chain A
residue 371
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
25) chain B
residue 118
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
26) chain B
residue 152
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
27) chain B
residue 276
type BINDING
sequence E
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
28) chain B
residue 292
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071
source Swiss-Prot : SWS_FT_FI3
29) chain A
residue 293
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
30) chain D
residue 293
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
31) chain D
residue 297
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
32) chain D
residue 324
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
33) chain A
residue 297
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
34) chain A
residue 324
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
35) chain B
residue 293
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
36) chain B
residue 297
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
37) chain B
residue 324
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
38) chain C
residue 293
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
39) chain C
residue 297
type BINDING
sequence G
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
40) chain C
residue 324
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI4
41) chain A
residue 345
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI5
42) chain B
residue 345
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI5
43) chain C
residue 345
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI5
44) chain D
residue 345
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ, ECO:0007744|PDB:3CL0
source Swiss-Prot : SWS_FT_FI5
45) chain A
residue 347
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ
source Swiss-Prot : SWS_FT_FI6
46) chain B
residue 347
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ
source Swiss-Prot : SWS_FT_FI6
47) chain C
residue 347
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ
source Swiss-Prot : SWS_FT_FI6
48) chain D
residue 347
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:16915235, ECO:0000269|PubMed:18480754, ECO:0007744|PDB:2HTY, ECO:0007744|PDB:3CKZ
source Swiss-Prot : SWS_FT_FI6

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