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eF-site ID
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2hsq-AB |
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PDB Code
|
2hsq |
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Chain
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A, B |
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click to enlarge
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Title
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Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site 2 (residues 565-587) |
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Classification
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CELL ADHESION, STRUCTURAL PROTEIN |
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Compound
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Vinculin |
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Source
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Homo sapiens (Human) (IPAA_SHIFL) |
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Sequence
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A: |
MEHHHHHHMPVFHTRTIESILEPVAQQISHLVIMHEEKAI
PDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPA
FIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILS
GTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDL
VTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNT
VKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKM
SAEINEIIRVLQLTSWDEDAW
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| B: |
AIYEKAKEVSSALSKVLSKIDDT
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Description
|
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Functional site
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|
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1)
|
chain |
A |
| residue |
162-182 |
| type |
prosite |
| sequence |
KNLGPGMTKMAKMIDERQQEL
|
| description |
VINCULIN_1 Vinculin family talin-binding region signature. KnLgpgMtkMakmideRQQEL
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| source |
prosite : PS00663
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2)
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chain |
A |
| residue |
97 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P85972
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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3)
|
chain |
A |
| residue |
173 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI2
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