eF-site ID 2hqu-ABC
PDB Code 2hqu
Chain A, B, C

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Title Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion
Classification HYDROLASE
Compound Deoxyuridine 5'-triphosphate nucleotidohydrolase
Source Homo sapiens (Human) (DUT_HUMAN)
Sequence A:  MQLRFARLSEHATAPTRRAAGYDLYSAYDYTIPPMEKAVV
KTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYR
GNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQ
ALDDTERGSGGFGSTGKN
B:  MQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEK
AVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDE
DYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIE
EVQALDDTERGSGGFGSTGKN
C:  MQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEK
AVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDE
DYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIE
EVQF
Description


Functional site
1) chain A
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE MG A 998
source : AC4
2) chain C
residue 95
type
sequence D
description BINDING SITE FOR RESIDUE MG A 998
source : AC4
3) chain C
residue 72
type
sequence I
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
4) chain C
residue 74
type
sequence L
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
5) chain C
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
6) chain C
residue 103
type
sequence E
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
7) chain C
residue 105
type
sequence Y
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
8) chain C
residue 106
type
sequence R
description BINDING SITE FOR RESIDUE CL C 999
source : AC5
9) chain A
residue 85
type
sequence R
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
10) chain A
residue 86
type
sequence S
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
11) chain A
residue 87
type
sequence G
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
12) chain A
residue 131
type
sequence Q
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
13) chain B
residue 98
type
sequence A
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
14) chain B
residue 99
type
sequence G
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
15) chain B
residue 100
type
sequence V
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
16) chain B
residue 101
type
sequence I
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
17) chain B
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
18) chain B
residue 105
type
sequence Y
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
19) chain B
residue 110
type
sequence G
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
20) chain C
residue 158
type
sequence F
description BINDING SITE FOR RESIDUE DUP A 777
source : AC6
21) chain A
residue 98
type
sequence A
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
22) chain A
residue 99
type
sequence G
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
23) chain A
residue 100
type
sequence V
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
24) chain A
residue 101
type
sequence I
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
25) chain A
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
26) chain A
residue 105
type
sequence Y
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
27) chain A
residue 110
type
sequence G
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
28) chain B
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
29) chain B
residue 157
type
sequence G
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
30) chain B
residue 158
type
sequence F
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
31) chain B
residue 159
type
sequence G
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
32) chain B
residue 160
type
sequence S
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
33) chain B
residue 161
type
sequence T
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
34) chain C
residue 85
type
sequence R
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
35) chain C
residue 86
type
sequence S
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
36) chain C
residue 87
type
sequence G
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
37) chain C
residue 131
type
sequence Q
description BINDING SITE FOR RESIDUE DUP B 777
source : AC7
38) chain A
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
39) chain A
residue 157
type
sequence G
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
40) chain A
residue 158
type
sequence F
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
41) chain A
residue 159
type
sequence G
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
42) chain A
residue 160
type
sequence S
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
43) chain A
residue 161
type
sequence T
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
44) chain B
residue 85
type
sequence R
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
45) chain B
residue 86
type
sequence S
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
46) chain B
residue 87
type
sequence G
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
47) chain B
residue 131
type
sequence Q
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
48) chain C
residue 98
type
sequence A
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
49) chain C
residue 99
type
sequence G
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
50) chain C
residue 100
type
sequence V
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
51) chain C
residue 101
type
sequence I
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
52) chain C
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
53) chain C
residue 105
type
sequence Y
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
54) chain C
residue 110
type
sequence G
description BINDING SITE FOR RESIDUE DUP C 777
source : AC8
55) chain A
residue 85
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
56) chain A
residue 153
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
57) chain A
residue 158
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
58) chain B
residue 85
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
59) chain B
residue 153
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
60) chain B
residue 158
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
61) chain C
residue 80
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI1
62) chain A
residue 99
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2
63) chain A
residue 110
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2
64) chain B
residue 99
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2
65) chain B
residue 110
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2
66) chain C
residue 94
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2
67) chain C
residue 105
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW
source Swiss-Prot : SWS_FT_FI2

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