eF-site ID 2hp4-AB PDB Code 2hp4 Chain A, B click to enlarge Title Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor Classification IMMUNE SYSTEM Compound T-cell surface glycoprotein CD8 alpha chain Source Homo sapiens (Human) (CD8A_HUMAN) Sequence A:  SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGASWLFQPR GAAASPTFLLYLNQNKPKAAEGLDTQRFSGKRLGDTFVLT LSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPA B:  SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGASWLFQPR GAAASPTFLLYLNQNKPKAAEGLDTQRFSGKRLGDTFVLT LSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPA Description Functional site 1) chain A residue 4 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 2) chain B residue 7 type sequence P description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 3) chain B residue 10 type sequence R description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 4) chain B residue 21 type sequence K description BINDING SITE FOR RESIDUE SO4 A 301 source : AC1 5) chain A residue 7 type sequence P description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 6) chain A residue 10 type sequence R description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 7) chain A residue 21 type sequence K description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 8) chain B residue 4 type sequence R description BINDING SITE FOR RESIDUE SO4 A 302 source : AC2 9) chain B residue 53 type sequence N description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 10) chain B residue 54 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 11) chain B residue 55 type sequence N description BINDING SITE FOR RESIDUE SO4 B 303 source : AC3 12) chain A residue 53 type sequence N description BINDING SITE FOR RESIDUE SO4 A 304 source : AC4 13) chain A residue 54 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 304 source : AC4 14) chain A residue 55 type sequence N description BINDING SITE FOR RESIDUE SO4 A 304 source : AC4 15) chain A residue 23 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 16) chain A residue 74 type sequence G description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 17) chain A residue 75 type sequence D description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 18) chain A residue 76 type sequence T description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 19) chain B residue 23 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 20) chain B residue 75 type sequence D description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 21) chain B residue 76 type sequence T description BINDING SITE FOR RESIDUE SO4 A 305 source : AC5 22) chain A residue 1 type sequence S description BINDING SITE FOR RESIDUE GOL A 401 source : AC6 23) chain A residue 106 type sequence H description BINDING SITE FOR RESIDUE GOL A 401 source : AC6 24) chain B residue 1 type sequence S description BINDING SITE FOR RESIDUE GOL B 402 source : AC7 25) chain B residue 106 type sequence H description BINDING SITE FOR RESIDUE GOL B 402 source : AC7 26) chain A residue 37 type sequence F description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 27) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 28) chain A residue 49 type sequence L description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 29) chain A residue 68 type sequence F description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 30) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 31) chain A residue 92 type sequence Y description BINDING SITE FOR RESIDUE GOL A 403 source : AC8 32) chain B residue 49 type sequence L description BINDING SITE FOR RESIDUE GOL B 404 source : AC9 33) chain B residue 88 type sequence N description BINDING SITE FOR RESIDUE GOL B 404 source : AC9 34) chain B residue 92 type sequence Y description BINDING SITE FOR RESIDUE GOL B 404 source : AC9

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