eF-site ID 2hko-A
PDB Code 2hko
Chain A

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Title Crystal structure of LSD1
Classification OXIDOREDUCTASE
Compound Lysine-specific histone demethylase 1
Source Homo sapiens (Human) (LSD1_HUMAN)
Sequence A:  GVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLF
IRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRV
HSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLA
AARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAM
VVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPK
EKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQAL
EVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLK
EKIKELHQQYKEAITAEFLVKSKHRDLTALCKEYDELAET
QGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAE
GLDIKLNTAVRQVQYTASGCEVIAVNTRSTSQTFIYKCDA
VLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKA
PILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAV
PQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRI
ADQFLGA
Description


Functional site
1) chain A
residue 285
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
2) chain A
residue 287
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
3) chain A
residue 288
type
sequence V
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
4) chain A
residue 289
type
sequence S
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
5) chain A
residue 307
type
sequence L
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
6) chain A
residue 308
type
sequence E
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
7) chain A
residue 309
type
sequence A
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
8) chain A
residue 310
type
sequence R
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
9) chain A
residue 314
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
10) chain A
residue 315
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
11) chain A
residue 316
type
sequence R
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
12) chain A
residue 329
type
sequence L
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
13) chain A
residue 330
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
14) chain A
residue 331
type
sequence A
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
15) chain A
residue 332
type
sequence M
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
16) chain A
residue 333
type
sequence V
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
17) chain A
residue 588
type
sequence T
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
18) chain A
residue 589
type
sequence A
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
19) chain A
residue 590
type
sequence V
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
20) chain A
residue 624
type
sequence T
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
21) chain A
residue 625
type
sequence L
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
22) chain A
residue 626
type
sequence P
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
23) chain A
residue 659
type
sequence L
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
24) chain A
residue 751
type
sequence W
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
25) chain A
residue 756
type
sequence W
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
26) chain A
residue 760
type
sequence S
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
27) chain A
residue 761
type
sequence Y
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
28) chain A
residue 800
type
sequence G
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
29) chain A
residue 801
type
sequence E
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
30) chain A
residue 809
type
sequence A
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
31) chain A
residue 810
type
sequence T
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
32) chain A
residue 811
type
sequence V
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
33) chain A
residue 814
type
sequence A
description BINDING SITE FOR RESIDUE FAD A 2762
source : AC1
34) chain A
residue 442
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI3
35) chain A
residue 503
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020
source Swiss-Prot : SWS_FT_FI4
36) chain A
residue 289
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
37) chain A
residue 308
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
38) chain A
residue 310
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
39) chain A
residue 316
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
40) chain A
residue 332
type BINDING
sequence M
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
41) chain A
residue 801
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
42) chain A
residue 810
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1
source Swiss-Prot : SWS_FT_FI1
43) chain A
residue 611
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2

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