eF-site ID 2hhe-B PDB Code 2hhe Chain B click to enlarge Title OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN Classification OXYGEN TRANSPORT Compound HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Source Homo sapiens (Human) (HBB_HUMAN) Sequence B:  MLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRF FESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNL KGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKE FTPPVQAAYQKVVAGVANALAHKYH Description Functional site 1) chain B residue 38 type sequence T description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 2) chain B residue 41 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 3) chain B residue 42 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 4) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 5) chain B residue 66 type sequence K description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 6) chain B residue 67 type sequence V description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 7) chain B residue 70 type sequence A description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 8) chain B residue 88 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 9) chain B residue 92 type sequence H description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 10) chain B residue 96 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 11) chain B residue 102 type sequence N description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 12) chain B residue 103 type sequence F description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 13) chain B residue 106 type sequence L description BINDING SITE FOR RESIDUE HEM B 147 source : AC2 14) chain B residue 8 type SITE sequence K description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 15) chain B residue 75 type SITE sequence L description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 16) chain B residue 85 type SITE sequence F description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 93 type SITE sequence C description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 105 type SITE sequence L description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 111 type SITE sequence V description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 20) chain B residue 120 type SITE sequence K description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 21) chain B residue 123 type SITE sequence T description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 129 type SITE sequence A description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 23) chain B residue 141 type SITE sequence L description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 145 type SITE sequence Y description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 26 type SITE sequence E description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 30 type SITE sequence R description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 27) chain B residue 36 type SITE sequence P description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 28) chain B residue 38 type SITE sequence T description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 46 type SITE sequence G description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 53 type SITE sequence A description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 31) chain B residue 57 type SITE sequence N description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 72 type SITE sequence S description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 60 type SITE sequence V description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 34) chain B residue 83 type SITE sequence G description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 35) chain B residue 96 type SITE sequence L description Not glycated => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI5 36) chain B residue 10 type MOD_RES sequence A description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 37) chain B residue 45 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 38) chain B residue 13 type MOD_RES sequence A description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 39) chain B residue 51 type MOD_RES sequence P description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 40) chain B residue 88 type MOD_RES sequence L description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7 41) chain B residue 60 type MOD_RES sequence V description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI8 42) chain B residue 83 type MOD_RES sequence G description N6-acetyllysine => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI8 43) chain B residue 94 type MOD_RES sequence D description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI9 44) chain B residue 145 type CARBOHYD sequence Y description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI12 45) chain B residue 3 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 46) chain B residue 83 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 47) chain B residue 144 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI1 48) chain B residue 145 type MOD_RES sequence Y description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 source Swiss-Prot : SWS_FT_FI10 49) chain B residue 9 type CARBOHYD sequence S description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI11 50) chain B residue 18 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI11 51) chain B residue 67 type CARBOHYD sequence V description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI11 52) chain B residue 121 type CARBOHYD sequence E description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI11 53) chain B residue 93 type BINDING sequence C description proximal binding residue source Swiss-Prot : SWS_FT_FI3 54) chain B residue 64 type BINDING sequence G description distal binding residue source Swiss-Prot : SWS_FT_FI2

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