eF-site ID 2hgt-HJL PDB Code 2hgt Chain H, J, L click to enlarge Title STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN Classification HYDROLASE/HYDROLASE INHIBITOR Compound ALPHA-THROMBIN (SMALL SUBUNIT) Source null (HIR2_HIRME) Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKETWGQPSVLQVVNLP IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL KKWIQKVIDQFGE J:  DFEEIP L:  SGEADCGLRPLFEKKSLEDKTERELLESYIDGR Description (1)  ALPHA-THROMBIN (E.C.3.4.21.5) COMPLEX WITH HIRULOG I (CLEAVED BETWEEN ARG 3 AND PRO 4) Functional site 1) chain H residue 57 type sequence H description source : CAT 2) chain H residue 102 type sequence D description source : CAT 3) chain H residue 195 type sequence S description source : CAT 4) chain H residue 57 type sequence H description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 5) chain H residue 60 type sequence L description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 6) chain H residue 97 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 7) chain H residue 99 type sequence L description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 8) chain H residue 189 type sequence D description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 9) chain H residue 190 type sequence A description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 10) chain H residue 192 type sequence E description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 11) chain H residue 193 type sequence G description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 12) chain H residue 194 type sequence D description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 13) chain H residue 195 type sequence S description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 14) chain H residue 214 type sequence S description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 15) chain H residue 215 type sequence W description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 16) chain H residue 216 type sequence G description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 17) chain H residue 219 type sequence G description BINDING SITE FOR CHAIN I OF HIRUDIN ANALOG source : AC1 18) chain H residue 34 type sequence F description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 19) chain H residue 38 type sequence Q description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 20) chain H residue 73 type sequence R description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 21) chain H residue 74 type sequence T description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 22) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 23) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 24) chain H residue 76 type sequence Y description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 25) chain H residue 82 type sequence I description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 26) chain H residue 151 type sequence Q description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 27) chain H residue 153 type sequence S description BINDING SITE FOR CHAIN J OF HIRUDIN ANALOG source : AC2 28) chain H residue 102 type MOD_RES sequence D description Sulfotyrosine => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain H residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain H residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 31) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 32) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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