eF-site ID 2he8-A PDB Code 2he8 Chain A click to enlarge Title Crystal structure of 17alpha-hydroxysteroid dehydrogenase in its apo-form Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1, member C21 Source (Q9CX32_MOUSE) Sequence A:  CHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDA GFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSK VWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKP GEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIG VSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLD FCKSKDIVLVAYGVLGTGGWVDQNSPVLLDEPVLGSMAKK YNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQ LSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY Description Functional site 1) chain A residue 219 type sequence L description BINDING SITE FOR RESIDUE ACT A 501 source : AC1 2) chain A residue 253 type sequence A description BINDING SITE FOR RESIDUE ACT A 501 source : AC1 3) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE ACT A 501 source : AC1 4) chain A residue 276 type sequence R description BINDING SITE FOR RESIDUE ACT A 501 source : AC1 5) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE ACT A 502 source : AC2 6) chain A residue 78 type sequence D description BINDING SITE FOR RESIDUE ACT A 502 source : AC2 7) chain A residue 79 type sequence I description BINDING SITE FOR RESIDUE ACT A 502 source : AC2 8) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE ACT A 503 source : AC3 9) chain A residue 227 type sequence W description BINDING SITE FOR RESIDUE ACT A 503 source : AC3 10) chain A residue 103 type sequence L description BINDING SITE FOR RESIDUE ACT A 504 source : AC4 11) chain A residue 107 type sequence Q description BINDING SITE FOR RESIDUE ACT A 504 source : AC4 12) chain A residue 108 type sequence F description BINDING SITE FOR RESIDUE ACT A 504 source : AC4 13) chain A residue 246 type sequence K description BINDING SITE FOR RESIDUE ACT A 504 source : AC4 14) chain A residue 143 type sequence D description BINDING SITE FOR RESIDUE BME A 601 source : AC5 15) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE BME A 601 source : AC5 16) chain A residue 175 type sequence M description BINDING SITE FOR RESIDUE BME A 601 source : AC5 17) chain A residue 275 type sequence E description BINDING SITE FOR RESIDUE BME A 601 source : AC5 18) chain A residue 276 type sequence R description BINDING SITE FOR RESIDUE BME A 601 source : AC5 19) chain A residue 29 type sequence C description BINDING SITE FOR RESIDUE BME A 602 source : AC6 20) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE BME A 602 source : AC6 21) chain A residue 200 type sequence M description BINDING SITE FOR RESIDUE GOL A 701 source : AC7 22) chain A residue 259 type sequence Y description BINDING SITE FOR RESIDUE GOL A 701 source : AC7 23) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE GOL A 701 source : AC7 24) chain A residue 297 type sequence D description BINDING SITE FOR RESIDUE GOL A 701 source : AC7 25) chain A residue 6 type sequence H description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 26) chain A residue 17 type sequence P description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 27) chain A residue 18 type sequence V description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 28) chain A residue 19 type sequence L description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 29) chain A residue 45 type sequence G description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 30) chain A residue 47 type sequence H description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 31) chain A residue 281 type sequence M description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 32) chain A residue 284 type sequence F description BINDING SITE FOR RESIDUE GOL A 703 source : AC8 33) chain A residue 20 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 50 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 216 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 270 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 84 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 151-168 type prosite sequence MEKCKDAGLTKSIGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MekckdaglTKSIGVSNF source prosite : PS00062 41) chain A residue 55 type ACT_SITE sequence Y description Proton donor source Swiss-Prot : SWS_FT_FI1 42) chain A residue 31 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 43) chain A residue 117 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI3

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