eF-site ID 2hct-A PDB Code 2hct Chain A click to enlarge Title Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities Classification HYDROLASE Compound ADP-ribosyl cyclase 1 Source Homo sapiens (Human) (CD38_HUMAN) Sequence A:  RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQS VWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILL WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFD TSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV HVMLDGSRSKIFDKDSTFGSVGVHNLQPEKVQTLEAWVIH GGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF LQCVKNPEDSSC Description Functional site 1) chain A residue 125 type sequence W description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 2) chain A residue 126 type sequence S description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 3) chain A residue 127 type sequence R description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 4) chain A residue 145 type sequence L description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 5) chain A residue 146 type sequence E description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 6) chain A residue 155 type sequence D description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 7) chain A residue 156 type sequence D description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 8) chain A residue 189 type sequence W description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 9) chain A residue 193 type sequence S description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 10) chain A residue 220 type sequence S description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 11) chain A residue 221 type sequence T description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 12) chain A residue 222 type sequence F description BINDING SITE FOR RESIDUE NMN A 301 source : AC1 13) chain A residue 100 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 209 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 119 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 201 type ACT_SITE sequence C description ACT_SITE => ECO:0000305|PubMed:7961800 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 164 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 219 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI4

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