eF-site ID 2hcn-A PDB Code 2hcn Chain A click to enlarge Title Crystal structure of RNA dependent RNA polymerase domain from west nile virus Classification TRANSFERASE Compound RNA-directed RNA polymerase (NS5) Source Kunjin virus (strain MRM61C) (POLG_KUNJM) Sequence A:  LVNGVVRLLSKPWDTITTKAPEPPEGVKYVLNETTNWLWA FLAREKRPRMCSREEFIRKVNSNAAQWRSAREAVEDPKFW EMVDEEREAHLRGECHTCRAIWFMWLGARFLEFEALGFLN EDHWLGRKNSGGGVEGLGLQKLGYILREVGTRPGGRIYAD DTAGWDTRITRADLENEAKVLELLDGEHRRLARAIIELTY RSGQVVTYALNTFTNLAVQLVRMMEGEGVIGPDDVEKLTK GKGPKVRTWLSENGEERLSRMAVSGDDCVVKPLDDRFATS LHFLNAMSKVRKDIQEWKPSTGWYDWQQVPFCSNHFTELI MKDGRTLVTPCRGQDELVGRARISPNVRDTACLAKSYAQM WLLLYFHRRDLRLMANAICSAVPVNWVPTGRTTWSIHAGG EWMTTEDMLEVWNRVWIEENEWMEDKTPVEKWSDVPYSGK REDIWCGSLIGTRARATWAENIQVAINQVRSIIGDEKYVD YMSSLK Description Functional site 1) chain A residue 536 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 2) chain A residue 669 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 3) chain A residue 440 type sequence E description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 4) chain A residue 444 type sequence H description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 5) chain A residue 449 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 6) chain A residue 452 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC2 7) chain A residue 717 type sequence H description BINDING SITE FOR RESIDUE ZN A 3 source : AC3 8) chain A residue 733 type sequence C description BINDING SITE FOR RESIDUE ZN A 3 source : AC3 9) chain A residue 852 type sequence C description BINDING SITE FOR RESIDUE ZN A 3 source : AC3 10) chain A residue 440 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 444 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 449 type BINDING sequence C description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 452 type BINDING sequence C description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 717 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 733 type BINDING sequence C description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 852 type BINDING sequence C description BINDING => ECO:0000269|PubMed:17287213 source Swiss-Prot : SWS_FT_FI1

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