eF-site ID 2h13-A
PDB Code 2h13
Chain A

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Title Crystal structure of WDR5/histone H3 complex
Classification TRANSCRIPTION
Compound WD-repeat protein 5
Source Homo sapiens (Human) (2H13)
Sequence A:  KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI
WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTL
KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE
SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY
DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA
ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG
KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP
TENIIASAALENDKTIKLWKSDC
Description (1)  WD-repeat protein 5, histone H3 lys-4 dimethylated


Functional site

1) chain A
residue 107
type SITE
sequence D
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 133
type SITE
sequence F
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 263
type SITE
sequence F
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 322
type SITE
sequence E
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 102-116
type prosite
sequence LVSASDDKTLKIWDV
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

6) chain A
residue 144-158
type prosite
sequence IVSGSFDESVRIWDV
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

7) chain A
residue 186-200
type prosite
sequence IVSSSYDGLCRIWDT
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

8) chain A
residue 274-288
type prosite
sequence IVSGSEDNLVYIWNL
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

9) chain A
residue 112
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 46
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI3


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