eF-site ID 2gy7-AB PDB Code 2gy7 Chain A, B click to enlarge Title Angiopoietin-2/Tie2 Complex Crystal Structure Classification SIGNALING PROTEIN Compound Angiopoietin-2 Source (TIE2_HUMAN) Sequence A:  EFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGG GGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEF VSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNY RIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQ MLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKG SGYSLKATTMMIRPAD B:  AMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFE ALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC EGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNIS FKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQ PQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNH LCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGR TCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEAC HPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCER EGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEE MTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVW VCSVNTVAGMVEKPFNISVKVLP Description (1)  Angiopoietin-2, Angiopoietin-1 receptor (E.C.2.7.10.1) Functional site 1) chain B residue 240-251 type prosite sequence CICPPGFMGRTC description EGF_1 EGF-like domain signature 1. CiCppGfmGRtC source prosite : PS00022 2) chain B residue 287-298 type prosite sequence CSCATGWKGLQC description EGF_1 EGF-like domain signature 1. CiCppGfmGRtC source prosite : PS00022 3) chain B residue 329-340 type prosite sequence CLCSPGWQGLQC description EGF_1 EGF-like domain signature 1. CiCppGfmGRtC source prosite : PS00022 4) chain B residue 240-255 type prosite sequence CICPPGFMGRTCEKAC description EGF_2 EGF-like domain signature 2. CiCppGFmgrtcekaC source prosite : PS01186 5) chain B residue 287-302 type prosite sequence CSCATGWKGLQCNEAC description EGF_2 EGF-like domain signature 2. CiCppGFmgrtcekaC source prosite : PS01186 6) chain B residue 329-340 type prosite sequence CLCSPGWQGLQC description EGF_2 EGF-like domain signature 2. CiCppGFmgrtcekaC source prosite : PS01186 7) chain A residue 431 type CARBOHYD sequence D description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16732286 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 140 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16732286 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 433 type CARBOHYD sequence C description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16732286 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 435 type CARBOHYD sequence C description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16732286 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 438 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 158 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 399 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 445-457 type prosite sequence WWFDACGPSNLNG description FIBRINOGEN_C_1 Fibrinogen C-terminal domain signature. WWFdaCgpSnlNG source prosite : PS00514

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