eF-site ID 2gvj-A PDB Code 2gvj Chain A click to enlarge Title Crystal Structure of Human NMPRTase in complex with FK866 Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence A:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGXKQKXWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNIE Description (1)  Nicotinamide phosphoribosyltransferase (E.C.2.4.2.12) Functional site 1) chain A residue 18 type sequence Y description BINDING SITE FOR RESIDUE DGB B 501 source : AC1 2) chain A residue 189 type sequence K description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 3) chain A residue 191 type sequence H description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 4) chain A residue 193 type sequence F description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 5) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 6) chain A residue 219 type sequence D description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 7) chain A residue 242 type sequence V description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 8) chain A residue 244 type sequence A description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 9) chain A residue 275 type sequence S description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 10) chain A residue 307 type sequence P description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 11) chain A residue 311 type sequence R description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 12) chain A residue 349 type sequence R description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 13) chain A residue 350 type sequence V description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 14) chain A residue 376 type sequence E description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 15) chain A residue 378 type sequence I description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 16) chain A residue 379 type sequence A description BINDING SITE FOR RESIDUE DGB A 502 source : AC2 17) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 18) chain A residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 19) chain A residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 20) chain A residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 21) chain A residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 22) chain A residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 23) chain A residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 24) chain A residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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