eF-site ID 2gvg-A PDB Code 2gvg Chain A click to enlarge Title Crystal Structure of human NMPRTase and its complex with NMN Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence A:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTKGYKL LPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSG GGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNK RSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFK NGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 A 601 source : AC1 2) chain A residue 246 type sequence E description BINDING SITE FOR RESIDUE PO4 A 601 source : AC1 3) chain A residue 247 type sequence H description BINDING SITE FOR RESIDUE PO4 A 601 source : AC1 4) chain A residue 311 type sequence R description BINDING SITE FOR RESIDUE PO4 A 601 source : AC1 5) chain A residue 313 type sequence D description BINDING SITE FOR RESIDUE PO4 A 601 source : AC1 6) chain A residue 18 type sequence Y description BINDING SITE FOR RESIDUE PO4 C 605 source : AC5 7) chain A residue 392 type sequence R description BINDING SITE FOR RESIDUE PO4 A 606 source : AC6 8) chain A residue 398 type sequence S description BINDING SITE FOR RESIDUE PO4 A 606 source : AC6 9) chain A residue 400 type sequence K description BINDING SITE FOR RESIDUE PO4 A 606 source : AC6 10) chain A residue 193 type sequence F description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 11) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 12) chain A residue 219 type sequence D description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 13) chain A residue 311 type sequence R description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 14) chain A residue 313 type sequence D description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 15) chain A residue 353 type sequence G description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 16) chain A residue 354 type sequence D description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 17) chain A residue 383 type sequence G description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 18) chain A residue 384 type sequence G description BINDING SITE FOR RESIDUE NMN A 501 source : BC4 19) chain A residue 16 type sequence D description BINDING SITE FOR RESIDUE NMN C 503 source : BC6 20) chain A residue 18 type sequence Y description BINDING SITE FOR RESIDUE NMN C 503 source : BC6 21) chain A residue 392 type sequence R description BINDING SITE FOR RESIDUE NMN C 503 source : BC6 22) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 23) chain A residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 24) chain A residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 25) chain A residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 26) chain A residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 27) chain A residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 28) chain A residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 29) chain A residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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