eF-site ID 2gvg-F PDB Code 2gvg Chain F click to enlarge Title Crystal Structure of human NMPRTase and its complex with NMN Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence F:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENKGY KLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFG SGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADP NKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTV FKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain F residue 18 type sequence Y description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 2) chain F residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 3) chain F residue 246 type sequence E description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 4) chain F residue 247 type sequence H description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 5) chain F residue 311 type sequence R description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 6) chain F residue 313 type sequence D description BINDING SITE FOR RESIDUE PO4 F 611 source : BC2 7) chain F residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 F 612 source : BC3 8) chain F residue 392 type sequence R description BINDING SITE FOR RESIDUE PO4 F 612 source : BC3 9) chain F residue 398 type sequence S description BINDING SITE FOR RESIDUE PO4 F 612 source : BC3 10) chain F residue 18 type sequence Y description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 11) chain F residue 193 type sequence F description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 12) chain F residue 196 type sequence R description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 13) chain F residue 219 type sequence D description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 14) chain F residue 311 type sequence R description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 15) chain F residue 313 type sequence D description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 16) chain F residue 384 type sequence G description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 17) chain F residue 392 type sequence R description BINDING SITE FOR RESIDUE NMN F 506 source : BC9 18) chain F residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 19) chain F residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 20) chain F residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 21) chain F residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 22) chain F residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 23) chain F residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 24) chain F residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 25) chain F residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 26) chain F residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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