eF-site ID 2gvg-D PDB Code 2gvg Chain D click to enlarge Title Crystal Structure of human NMPRTase and its complex with NMN Classification TRANSFERASE Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence D:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain D residue 196 type sequence R description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 2) chain D residue 246 type sequence E description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 3) chain D residue 247 type sequence H description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 4) chain D residue 311 type sequence R description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 5) chain D residue 313 type sequence D description BINDING SITE FOR RESIDUE PO4 D 607 source : AC7 6) chain D residue 384 type sequence G description BINDING SITE FOR RESIDUE PO4 E 608 source : AC8 7) chain D residue 18 type sequence Y description BINDING SITE FOR RESIDUE PO4 E 609 source : AC9 8) chain D residue 392 type sequence R description BINDING SITE FOR RESIDUE PO4 D 610 source : BC1 9) chain D residue 398 type sequence S description BINDING SITE FOR RESIDUE PO4 D 610 source : BC1 10) chain D residue 400 type sequence K description BINDING SITE FOR RESIDUE PO4 D 610 source : BC1 11) chain D residue 193 type sequence F description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 12) chain D residue 196 type sequence R description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 13) chain D residue 219 type sequence D description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 14) chain D residue 311 type sequence R description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 15) chain D residue 313 type sequence D description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 16) chain D residue 353 type sequence G description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 17) chain D residue 354 type sequence D description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 18) chain D residue 383 type sequence G description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 19) chain D residue 384 type sequence G description BINDING SITE FOR RESIDUE NMN D 504 source : BC7 20) chain D residue 16 type sequence D description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 21) chain D residue 18 type sequence Y description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 22) chain D residue 392 type sequence R description BINDING SITE FOR RESIDUE NMN E 505 source : BC8 23) chain D residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 24) chain D residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 25) chain D residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 26) chain D residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 27) chain D residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 28) chain D residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 29) chain D residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 30) chain D residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI3 31) chain D residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

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