eF-site ID 2gvf-C PDB Code 2gvf Chain C click to enlarge Title HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021 Classification HYDROLASE Compound polyprotein Source (NP_671491) Sequence C:  QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASP KGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLV TRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPA GHAVGLFRAAVCTRGVAKAVDFIPVENLETTM Description (1)  polyprotein Functional site 1) chain C residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN C 902 source : AC2 2) chain C residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN C 902 source : AC2 3) chain C residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN C 902 source : AC2 4) chain C residue 97 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 5) chain C residue 99 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 6) chain C residue 145 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 149 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI2 8) chain C residue 57 type ACT_SITE sequence H description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 9) chain C residue 81 type ACT_SITE sequence D description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1 10) chain C residue 139 type ACT_SITE sequence S description Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 source Swiss-Prot : SWS_FT_FI1

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