eF-site ID 2gv7-A PDB Code 2gv7 Chain A click to enlarge Title Structure of Matriptase in Complex with Inhibitor CJ-672 Classification HYDROLASE Compound Suppressor of tumorigenicity 14 Source Homo sapiens (Human) (ST14_HUMAN) Sequence A:  VVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSA AHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRL KRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPD ASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQT TCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEA DGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTG V Description (1)  Suppressor of tumorigenicity 14 (E.C.3.4.21.-) Functional site 1) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 2) chain A residue 58 type sequence C description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 3) chain A residue 60 type sequence I description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 4) chain A residue 60 type sequence I description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 5) chain A residue 60 type sequence I description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 6) chain A residue 99 type sequence F description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 7) chain A residue 146 type sequence Y description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 8) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 9) chain A residue 190 type sequence S description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 10) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 11) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 12) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 13) chain A residue 214 type sequence S description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 14) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 15) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 16) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 17) chain A residue 220 type sequence C description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 18) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE 672 A 245 source : AC1 19) chain A residue 164 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 21) chain A residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 22) chain A residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 23) chain A residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 24) chain A residue 189-200 type prosite sequence DSCQGDSGGPLS description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLS source prosite : PS00135

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