eF-site ID 2gst-AB PDB Code 2gst Chain A, B click to enlarge Title STRUCTURE OF THE XENOBIOTIC SUBSTRATE BINDING SITE OF A GLUTATHIONE S-TRANSFERASE AS REVEALED BY X-RAY CRYSTALLOGRAPHIC ANALYSIS OF PRODUCT COMPLEXES WITH THE DIASTEREOMERS OF 9-(S-GLUTATHIONYL)-10-HYDROXY-9, 10-DIHYDROPHENANTHRENE Classification GLUTATHIONE TRANSFERASE Compound GLUTATHIONE S-TRANSFERASE Source null (GSTM1_RAT) Sequence A:  PMILGYWNVRGLTHPIRLLLEYTDSSYEEKRYAMGDAPDY DRSQWLNEKFKLGLDFPNLPYLIDGSRKITQSNAIMRYLA RKHHLCGETEEERIRADIVENQVMDNRMQLIMLCYNPDFE KQKPEFLKTIPEKMKLYSEFLGKRPWFAGDKVTYVDFLAY DILDQYHIFEPKCLDAFPNLKDFLARFEGLKKISAYMKSS RYLSTPIFSKLAQWSNK B:  PMILGYWNVRGLTHPIRLLLEYTDSSYEEKRYAMGDAPDY DRSQWLNEKFKLGLDFPNLPYLIDGSRKITQSNAIMRYLA RKHHLCGETEEERIRADIVENQVMDNRMQLIMLCYNPDFE KQKPEFLKTIPEKMKLYSEFLGKRPWFAGDKVTYVDFLAY DILDQYHIFEPKCLDAFPNLKDFLARFEGLKKISAYMKSS RYLSTPIFSKLAQWSNK Description Functional site 1) chain A residue 128 type sequence K description BINDING SITE FOR RESIDUE SO4 A 218 source : AC1 2) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE SO4 A 219 source : AC2 3) chain A residue 109 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 219 source : AC2 4) chain A residue 6 type sequence Y description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 5) chain A residue 7 type sequence W description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 6) chain A residue 9 type sequence V description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 7) chain A residue 11 type sequence G description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 8) chain A residue 12 type sequence L description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 9) chain A residue 42 type sequence R description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 10) chain A residue 45 type sequence W description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 11) chain A residue 49 type sequence K description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 12) chain A residue 58 type sequence N description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 13) chain A residue 59 type sequence L description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 14) chain A residue 60 type sequence P description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 15) chain A residue 71 type sequence Q description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 16) chain A residue 72 type sequence S description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 17) chain A residue 111 type sequence I description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 18) chain A residue 115 type sequence Y description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 19) chain A residue 208 type sequence F description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 20) chain A residue 209 type sequence S description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 21) chain B residue 105 type sequence D description BINDING SITE FOR RESIDUE GPS A 220 source : AC3 22) chain A residue 105 type sequence D description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 23) chain B residue 6 type sequence Y description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 24) chain B residue 7 type sequence W description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 25) chain B residue 9 type sequence V description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 26) chain B residue 11 type sequence G description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 27) chain B residue 12 type sequence L description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 28) chain B residue 42 type sequence R description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 29) chain B residue 45 type sequence W description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 30) chain B residue 49 type sequence K description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 31) chain B residue 58 type sequence N description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 32) chain B residue 59 type sequence L description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 33) chain B residue 71 type sequence Q description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 34) chain B residue 72 type sequence S description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 35) chain B residue 111 type sequence I description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 36) chain B residue 208 type sequence F description BINDING SITE FOR RESIDUE GPS B 218 source : AC4 37) chain A residue 7 type BINDING sequence W description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 43 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 72 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 50 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 59 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 72 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 7 type BINDING sequence W description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 43 type BINDING sequence S description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 50 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 59 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 116 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 116 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 67 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3 50) chain A residue 205 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3 51) chain A residue 210 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3 52) chain B residue 67 type MOD_RES sequence R description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3 53) chain B residue 205 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3 54) chain B residue 210 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI3

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