eF-site ID 2gse-C
PDB Code 2gse
Chain C

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Title Crystal Structure of Human Dihydropyrimidinease-like 2
Classification HYDROLASE
Compound Dihydropyrimidinase-related protein 2
Source Homo sapiens (Human) (DPYL2_HUMAN)
Sequence C:  DRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGG
VKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTK
AALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCD
YSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRF
QLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILD
LGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITK
VMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKN
WAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHC
TFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGK
MDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDP
DSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVL
EDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLA
Description


Functional site
1) chain C
residue 349
type
sequence T
description BINDING SITE FOR RESIDUE CA C 1002
source : AC3
2) chain C
residue 465
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:O08553
source Swiss-Prot : SWS_FT_FI5
3) chain C
residue 32
type MOD_RES
sequence Y
description Phosphotyrosine; by FYN => ECO:0000269|PubMed:19652227
source Swiss-Prot : SWS_FT_FI1
4) chain C
residue 258
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:O08553
source Swiss-Prot : SWS_FT_FI2
5) chain C
residue 259
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P47942
source Swiss-Prot : SWS_FT_FI3
6) chain C
residue 431
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000250|UniProtKB:O08553
source Swiss-Prot : SWS_FT_FI4

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