eF-site ID 2gq2-C PDB Code 2gq2 Chain C click to enlarge Title Mycobacterium tuberculosis ThyX-NADP complex Classification TRANSFERASE Compound Thymidylate synthase thyX Source Mycobacterium tuberculosis (THYX_MYCTU) Sequence C:  TAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRAC YQSWSTATNAGYLRHIXDVGHFSVLEHASVSFYITGISRS CTHELIRHRHFSYSQLSQRYVPSRVVVPPGXEDDADLRHI LTEAADAARATYSELLAKLEARKQARQAARAVXPNATETR IVVTGNYRAWRHFIAXRASEHADVEIRRLAIECLRQLAAV APAVFADFEVTTLADGTEVATSPLA Description Functional site 1) chain C residue 87 type sequence R description BINDING SITE FOR RESIDUE IOD C 509 source : AC6 2) chain C residue 106 type sequence Q description BINDING SITE FOR RESIDUE IOD C 509 source : AC6 3) chain C residue 172 type sequence R description BINDING SITE FOR RESIDUE IOD C 509 source : AC6 4) chain C residue 98 type sequence H description BINDING SITE FOR RESIDUE IOD C 511 source : AC8 5) chain C residue 71 type sequence S description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 6) chain C residue 74 type sequence E description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 7) chain C residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 8) chain C residue 188 type sequence N description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 9) chain C residue 190 type sequence R description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 10) chain C residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 11) chain C residue 95 type sequence R description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 12) chain C residue 96 type sequence H description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 13) chain C residue 97 type sequence R description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 14) chain C residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 15) chain C residue 199 type sequence R description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 16) chain C residue 101 type sequence Y description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 17) chain C residue 102 type sequence S description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 18) chain C residue 103 type sequence Q description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 19) chain C residue 105 type sequence S description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 20) chain C residue 105 type sequence S description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 21) chain C residue 14 type sequence K description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 22) chain C residue 15 type sequence T description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 23) chain C residue 32 type sequence G description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 24) chain C residue 77 type sequence S description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 25) chain C residue 189 type sequence Y description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 26) chain C residue 222 type sequence V description BINDING SITE FOR RESIDUE GOL C 403 source : CC6 27) chain C residue 213 type sequence I description BINDING SITE FOR RESIDUE GOL C 407 source : CC9 28) chain C residue 240 type sequence E description BINDING SITE FOR RESIDUE GOL C 407 source : CC9 29) chain C residue 199 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000255|HAMAP-Rule:MF_01408 source Swiss-Prot : SWS_FT_FI1 30) chain C residue 71 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 31) chain C residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 32) chain C residue 103 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 33) chain C residue 188 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 34) chain C residue 194 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 35) chain C residue 87 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 36) chain C residue 172 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 37) chain C residue 92 type BINDING sequence E description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4 38) chain C residue 199 type BINDING sequence R description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4

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