eF-site ID 2gq2-D PDB Code 2gq2 Chain D click to enlarge Title Mycobacterium tuberculosis ThyX-NADP complex Classification TRANSFERASE Compound Thymidylate synthase thyX Source Mycobacterium tuberculosis (THYX_MYCTU) Sequence D:  TAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRAC YQSWSKPNPKTATNAGYLRHIXDVGHFSVLEHASVSFYIT GISRSCTHELIRHRHFSYSQLSQRYRVVVPPGXEDDADLR HILTEAADAARATYSELLAKLEALRRKQARQAARAVXPNA TETRIVVTGNYRAWRHFIAXRASEHADVEIRRLAIECLRQ LAAVAPAVFADFEVTTLADGTEVATS Description Functional site 1) chain D residue 87 type sequence R description BINDING SITE FOR RESIDUE IOD A 502 source : AC2 2) chain D residue 87 type sequence R description BINDING SITE FOR RESIDUE IOD D 503 source : AC3 3) chain D residue 239 type sequence T description BINDING SITE FOR RESIDUE IOD D 505 source : AC4 4) chain D residue 240 type sequence E description BINDING SITE FOR RESIDUE IOD D 505 source : AC4 5) chain D residue 206 type sequence V description BINDING SITE FOR RESIDUE IOD D 507 source : AC5 6) chain D residue 95 type sequence R description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 7) chain D residue 96 type sequence H description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 8) chain D residue 97 type sequence R description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 9) chain D residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 10) chain D residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 11) chain D residue 199 type sequence R description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 12) chain D residue 71 type sequence S description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 13) chain D residue 74 type sequence E description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 14) chain D residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 15) chain D residue 188 type sequence N description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 16) chain D residue 190 type sequence R description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 17) chain D residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 18) chain D residue 101 type sequence Y description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 19) chain D residue 102 type sequence S description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 20) chain D residue 103 type sequence Q description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 21) chain D residue 105 type sequence S description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 22) chain D residue 14 type sequence K description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 23) chain D residue 15 type sequence T description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 24) chain D residue 32 type sequence G description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 25) chain D residue 77 type sequence S description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 26) chain D residue 78 type sequence V description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 27) chain D residue 189 type sequence Y description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 28) chain D residue 222 type sequence V description BINDING SITE FOR RESIDUE GOL D 404 source : CC7 29) chain D residue 22 type sequence D description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 30) chain D residue 23 type sequence V description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 31) chain D residue 24 type sequence P description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 32) chain D residue 45 type sequence Q description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 33) chain D residue 47 type sequence W description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 34) chain D residue 210 type sequence R description BINDING SITE FOR RESIDUE GOL D 408 source : DC1 35) chain D residue 239 type sequence T description BINDING SITE FOR RESIDUE GOL D 408 source : DC1 36) chain D residue 240 type sequence E description BINDING SITE FOR RESIDUE GOL D 408 source : DC1 37) chain D residue 199 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000255|HAMAP-Rule:MF_01408 source Swiss-Prot : SWS_FT_FI1 38) chain D residue 71 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 39) chain D residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 40) chain D residue 103 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 41) chain D residue 188 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 42) chain D residue 194 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 43) chain D residue 87 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 44) chain D residue 172 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 45) chain D residue 92 type BINDING sequence E description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4 46) chain D residue 199 type BINDING sequence R description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4

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