eF-site ID 2gq2-B PDB Code 2gq2 Chain B click to enlarge Title Mycobacterium tuberculosis ThyX-NADP complex Classification TRANSFERASE Compound Thymidylate synthase thyX Source Mycobacterium tuberculosis (THYX_MYCTU) Sequence B:  ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRA CYQSWSKPKTATNAGYLRHIXDVGHFSVLEHASVSFYITG ISRSCTHELIRHRHFSYSQLSQRYVPSRVVVPPGXEDDAD LRHILTEAADAARATYSELLAKLEAKQARQAARAVXPNAT ETRIVVTGNYRAWRHFIAXRASEHADVEIRRLAIECLRQL AAVAPAVFADFEVTTLADGTEVATSP Description Functional site 1) chain B residue 177 type sequence N description BINDING SITE FOR RESIDUE IOD C 509 source : AC6 2) chain B residue 87 type sequence R description BINDING SITE FOR RESIDUE IOD B 510 source : AC7 3) chain B residue 172 type sequence R description BINDING SITE FOR RESIDUE IOD B 510 source : AC7 4) chain B residue 98 type sequence H description BINDING SITE FOR RESIDUE IOD C 511 source : AC8 5) chain B residue 103 type sequence Q description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 6) chain B residue 105 type sequence S description BINDING SITE FOR RESIDUE NAP B 300 source : BC9 7) chain B residue 95 type sequence R description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 8) chain B residue 96 type sequence H description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 9) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 10) chain B residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 11) chain B residue 199 type sequence R description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 12) chain B residue 71 type sequence S description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 13) chain B residue 74 type sequence E description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 14) chain B residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 15) chain B residue 188 type sequence N description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 16) chain B residue 190 type sequence R description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 17) chain B residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 18) chain B residue 14 type sequence K description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 19) chain B residue 15 type sequence T description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 20) chain B residue 31 type sequence G description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 21) chain B residue 32 type sequence G description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 22) chain B residue 78 type sequence V description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 23) chain B residue 189 type sequence Y description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 24) chain B residue 222 type sequence V description BINDING SITE FOR RESIDUE GOL B 402 source : CC5 25) chain B residue 81 type sequence Y description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 26) chain B residue 182 type sequence R description BINDING SITE FOR RESIDUE GOL D 405 source : CC8 27) chain B residue 199 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000255|HAMAP-Rule:MF_01408 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 194 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 29) chain B residue 71 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 30) chain B residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 31) chain B residue 103 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 32) chain B residue 188 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 33) chain B residue 87 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 172 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 92 type BINDING sequence E description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 199 type BINDING sequence R description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4

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