eF-site ID 2gq2-A PDB Code 2gq2 Chain A click to enlarge Title Mycobacterium tuberculosis ThyX-NADP complex Classification TRANSFERASE Compound Thymidylate synthase thyX Source Mycobacterium tuberculosis (THYX_MYCTU) Sequence A:  AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGR ACYQSWSKPNPTNAGYLRHIXDVGHFSVLEHASVSFYITG ISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGXED DADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRR KQARQAARAVXPNATETRIVVTGNYRAWRHFIAXRASEHA DVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATS PL Description Functional site 1) chain A residue 115 type sequence R description BINDING SITE FOR RESIDUE IOD A 501 source : AC1 2) chain A residue 87 type sequence R description BINDING SITE FOR RESIDUE IOD A 502 source : AC2 3) chain A residue 177 type sequence N description BINDING SITE FOR RESIDUE IOD D 503 source : AC3 4) chain A residue 98 type sequence H description BINDING SITE FOR RESIDUE IOD D 512 source : AC9 5) chain A residue 205 type sequence D description BINDING SITE FOR RESIDUE IOD D 514 source : BC2 6) chain A residue 121 type sequence G description BINDING SITE FOR RESIDUE IOD A 515 source : BC3 7) chain A residue 206 type sequence V description BINDING SITE FOR RESIDUE IOD A 515 source : BC3 8) chain A residue 101 type sequence Y description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 9) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 10) chain A residue 103 type sequence Q description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 11) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE NAP A 300 source : BC8 12) chain A residue 71 type sequence S description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 13) chain A residue 74 type sequence E description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 14) chain A residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 15) chain A residue 188 type sequence N description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 16) chain A residue 190 type sequence R description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 17) chain A residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP C 300 source : CC1 18) chain A residue 44 type sequence Y description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 19) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 20) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 21) chain A residue 70 type sequence F description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 22) chain A residue 71 type sequence S description BINDING SITE FOR RESIDUE PGE A 701 source : CC2 23) chain A residue 95 type sequence R description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 24) chain A residue 96 type sequence H description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 25) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 26) chain A residue 98 type sequence H description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 27) chain A residue 194 type sequence H description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 28) chain A residue 199 type sequence R description BINDING SITE FOR RESIDUE NAP D 300 source : CC3 29) chain A residue 14 type sequence K description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 30) chain A residue 15 type sequence T description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 31) chain A residue 32 type sequence G description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 32) chain A residue 77 type sequence S description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 33) chain A residue 189 type sequence Y description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 34) chain A residue 222 type sequence V description BINDING SITE FOR RESIDUE GOL A 401 source : CC4 35) chain A residue 199 type ACT_SITE sequence R description Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000255|HAMAP-Rule:MF_01408 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 71 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 37) chain A residue 95 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 38) chain A residue 103 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 39) chain A residue 188 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 40) chain A residue 194 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16139296, ECO:0007744|PDB:2AF6, ECO:0007744|PDB:3GWC, ECO:0007744|PDB:3HZG source Swiss-Prot : SWS_FT_FI2 41) chain A residue 87 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 172 type BINDING sequence R description in other chain => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 92 type BINDING sequence E description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4 44) chain A residue 199 type BINDING sequence R description BINDING => ECO:0000305|PubMed:16139296, ECO:0007744|PDB:2AF6 source Swiss-Prot : SWS_FT_FI4

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