eF-site ID 2gmx-B PDB Code 2gmx Chain B click to enlarge Title Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity Classification TRANSCRIPTION Compound Mitogen-activated protein kinase 8 Source Homo sapiens (Human) (JIP1_HUMAN) Sequence B:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK ILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENV DLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCP EFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEH NKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYD PSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE Description Functional site 1) chain B residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 2) chain B residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 B 701 source : AC3 3) chain B residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 701 source : AC3 4) chain B residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 5) chain B residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 6) chain B residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 7) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 8) chain B residue 30 type sequence K description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 9) chain B residue 32 type sequence I description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 10) chain B residue 40 type sequence V description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 11) chain B residue 53 type sequence A description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 12) chain B residue 55 type sequence K description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 13) chain B residue 108 type sequence M description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 14) chain B residue 109 type sequence E description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 15) chain B residue 110 type sequence L description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 16) chain B residue 111 type sequence M description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 17) chain B residue 112 type sequence D description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 18) chain B residue 114 type sequence N description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 19) chain B residue 158 type sequence V description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 20) chain B residue 168 type sequence L description BINDING SITE FOR RESIDUE 877 B 1001 source : AC6 21) chain B residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5

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