eF-site ID 2gmx-A PDB Code 2gmx Chain A click to enlarge Title Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity Classification TRANSCRIPTION Compound Mitogen-activated protein kinase 8 Source Homo sapiens (Human) (JIP1_HUMAN) Sequence A:  NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAI LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIG LLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHER MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI LDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVD LWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE FMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDP SEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEH Description Functional site 1) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 2) chain A residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 3) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 4) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 5) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 6) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 7) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 8) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 9) chain A residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 B 701 source : AC3 10) chain A residue 32 type sequence I description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 11) chain A residue 40 type sequence V description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 12) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 13) chain A residue 86 type sequence I description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 14) chain A residue 108 type sequence M description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 15) chain A residue 109 type sequence E description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 16) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 17) chain A residue 111 type sequence M description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 18) chain A residue 112 type sequence D description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 19) chain A residue 113 type sequence A description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 20) chain A residue 158 type sequence V description BINDING SITE FOR RESIDUE 877 A 901 source : AC5 21) chain A residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 25) chain A residue 61-163 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDC description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351 26) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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