eF-site ID 2gco-AB PDB Code 2gco Chain A, B click to enlarge Title Crystal structure of the human RhoC-GppNHp complex Classification SIGNALING PROTEIN Compound Rho-related GTP-binding protein RhoC Source null (RHOC_HUMAN) Sequence A:  HHHSSGLVPAAIRKKLVIVGDGACGKTCLLIVFSKDQFPE VYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPL SYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFXPNVPI ILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRIS AFGYLECSAKTKEGVREVFEMATRAGLQ B:  HHSSGLVPIRKKLVIVGDGACGKTCLLIVFSKDQFPVPTV FENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTD VILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNK KDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLE CSAKTKEGVREVFEMATRAGLQ Description Functional site 1) chain A residue 19 type sequence T description BINDING SITE FOR RESIDUE MG A 1002 source : AC1 2) chain A residue 37 type sequence T description BINDING SITE FOR RESIDUE MG A 1002 source : AC1 3) chain B residue 19 type sequence T description BINDING SITE FOR RESIDUE MG B 1004 source : AC2 4) chain B residue 37 type sequence T description BINDING SITE FOR RESIDUE MG B 1004 source : AC2 5) chain A residue 14 type sequence G description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 6) chain A residue 15 type sequence A description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 7) chain A residue 16 type sequence C description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 8) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 9) chain A residue 18 type sequence K description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 10) chain A residue 19 type sequence T description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 11) chain A residue 20 type sequence C description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 12) chain A residue 30 type sequence F description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 13) chain A residue 35 type sequence V description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 14) chain A residue 37 type sequence T description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 15) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 16) chain A residue 118 type sequence K description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 17) chain A residue 120 type sequence D description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 18) chain A residue 121 type sequence L description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 19) chain A residue 160 type sequence S description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 20) chain A residue 161 type sequence A description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 21) chain A residue 162 type sequence K description BINDING SITE FOR RESIDUE GNP A 1001 source : AC3 22) chain B residue 14 type sequence G description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 23) chain B residue 15 type sequence A description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 24) chain B residue 16 type sequence C description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 25) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 26) chain B residue 18 type sequence K description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 27) chain B residue 19 type sequence T description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 28) chain B residue 20 type sequence C description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 29) chain B residue 30 type sequence F description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 30) chain B residue 37 type sequence T description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 31) chain B residue 62 type sequence G description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 32) chain B residue 118 type sequence K description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 33) chain B residue 120 type sequence D description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 34) chain B residue 121 type sequence L description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 35) chain B residue 160 type sequence S description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 36) chain B residue 161 type sequence A description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 37) chain B residue 162 type sequence K description BINDING SITE FOR RESIDUE GNP B 1003 source : AC4 38) chain B residue 12 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 59 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 117 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 41 type MOD_RES sequence N description ADP-ribosylasparagine; by botulinum toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 37 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269|PubMed:24905543 source Swiss-Prot : SWS_FT_FI4

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