eF-site ID 2gbg-A
PDB Code 2gbg
Chain A

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Title rat DPP-IV with alkynyl cyanopyrrolidine #2
Classification HYDROLASE
Compound Dipeptidyl peptidase 4
Source ORGANISM_COMMON: Norway rat; ORGANISM_SCIENTIFIC: Rattus norvegicus;
Sequence A:  RRTYTLADYLKNTFRVKSYSLRWVSDSEYLYKQENNILLF
NAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYN
YVKQWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQ
EGHKLAYVWKNDIYVKIEPHLPSHRITSTGKENVIFNGIN
DWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYS
FYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSST
TTTIPMQITAPASVTTGDHYLCDVAWVSEDRISLQWLRRI
QNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRP
AEPHFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTF
ITKGAWEVISIEALTSDYLYYISNEYKEMPGGRNLYKIQL
TDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPG
LPLYTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDF
IVLNETRFWYQMILPPHFDKSKKYPLLIDVYAGPCSQKAD
AAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINK
RLGTLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVT
SMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP
EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQS
AQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMS
HFLQQCFSLR
Description (1)  Dipeptidyl peptidase 4 (EC 3.4.14.5)


Functional site

1) chain A
residue 123
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 900
source : AC1

2) chain A
residue 548
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 A 900
source : AC1

3) chain A
residue 741
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 900
source : AC1

4) chain A
residue 203
type
sequence E
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

5) chain A
residue 204
type
sequence E
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

6) chain A
residue 355
type
sequence F
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

7) chain A
residue 548
type
sequence Y
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

8) chain A
residue 631
type
sequence S
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

9) chain A
residue 632
type
sequence Y
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

10) chain A
residue 657
type
sequence V
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

11) chain A
residue 663
type
sequence Y
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

12) chain A
residue 667
type
sequence Y
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

13) chain A
residue 711
type
sequence N
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

14) chain A
residue 741
type
sequence H
description BINDING SITE FOR RESIDUE 1AD A 768
source : AC2

15) chain A
residue 631
type ACT_SITE
sequence S
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 709
type ACT_SITE
sequence D
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 741
type ACT_SITE
sequence H
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 148
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

19) chain A
residue 217
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 686
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

21) chain A
residue 83
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 90
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 227
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 319
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 521
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 323-337
type prosite
sequence MAICDYDKTTLVWNC
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. MAICdyDkTTLVWNC
source prosite : PS00678

27) chain A
residue 606-636
type prosite
sequence DQIEAARQFLKMGFVDSKRVAIWGWSYGGYV
description PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqieAarqFlkmgfvdskrvaiwGwSyGGYV
source prosite : PS00708


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