eF-site ID 2g9n-A
PDB Code 2g9n
Chain A

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Title Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A
Classification HYDROLASE
Compound Eukaryotic initiation factor 4A-I
Source Homo sapiens (Human) (IF4A1_HUMAN)
Sequence A:  GVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEXPSAIQQ
RAILPCIXGYDVIAQAQSGTGXTATFAISILQQIELDLXA
TQALVLAPTRELAQQIQXVVMALGDYMGASCHACIGNVRA
EVQXLQMEAPHIIVGTPGRVFDMLNRRYLSPXYIXMFVLD
EADEMLSRGFXDQIYDIFQXLNSNTQVVLLSATMPSDVLE
VTXXFMRDPIRILVXX
Description


Functional site

1) chain A
residue 76
type BINDING
sequence A
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 118
type MOD_RES
sequence X
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 174
type MOD_RES
sequence X
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 193
type MOD_RES
sequence X
description N6-acetyllysine => ECO:0000250|UniProtKB:P60843
source Swiss-Prot : SWS_FT_FI4

5) chain A
residue 146
type CROSSLNK
sequence X
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI5

6) chain A
residue 225
type CROSSLNK
sequence X
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI5

7) chain A
residue 180-188
type prosite
sequence VLDEADEML
description DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
source prosite : PS00039

8) chain A
residue 158
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI3


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