eF-site ID 2g9n-AB PDB Code 2g9n Chain A, B click to enlarge Title Structure of the DEAD domain of Human eukaryotic initiation factor 4A, eIF4A Classification HYDROLASE Compound Eukaryotic initiation factor 4A-I Source Homo sapiens (Human) (IF4A1_HUMAN) Sequence A:  GVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEXPSAIQQ RAILPCIXGYDVIAQAQSGTGXTATFAISILQQIELDLXA TQALVLAPTRELAQQIQXVVMALGDYMGASCHACIGNVRA EVQXLQMEAPHIIVGTPGRVFDMLNRRYLSPXYIXMFVLD EADEMLSRGFXDQIYDIFQXLNSNTQVVLLSATMPSDVLE VTXXFMRDPIRILVXX B:  IESNWNEIVDSFDDMNLSESLLRGIYAYGFEXPSAIQQRA ILPCIXGYDVIAQAQSGTGXTATFAISILQQIELDLXATQ ALVLAPTRELAQQIQXVVMALGDYMGASCHACIGGTNVRA EVQXLQMEAPHIIVGTPGRVFDMLNRRYLSPXYIXMFVLD EADEMLSRGFXDQIYDIFQXLNSNTQVVLLSATMPSDVLE VTXXFMRDPIRILVX Description Functional site 1) chain A residue 76 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 76 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 118 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 4) chain A residue 174 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 118 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 174 type MOD_RES sequence X description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 193 type MOD_RES sequence X description N6-acetyllysine => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI4 8) chain B residue 193 type MOD_RES sequence X description N6-acetyllysine => ECO:0000250|UniProtKB:P60843 source Swiss-Prot : SWS_FT_FI4 9) chain A residue 146 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 10) chain A residue 225 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 146 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 12) chain B residue 225 type CROSSLNK sequence X description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 13) chain A residue 180-188 type prosite sequence VLDEADEML description DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL source prosite : PS00039 14) chain A residue 158 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 158 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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