|
|
eF-site ID
|
2g45-A |
|
PDB Code
|
2g45 |
|
Chain
|
A |
|
click to enlarge
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Title
|
Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin |
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Classification
|
HYDROLASE |
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Compound
|
Ubiquitin carboxyl-terminal hydrolase 5 |
|
Source
|
null (UBIQ_HUMAN) |
|
|
Sequence
|
A: |
VRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNL
TDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTIT
PDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKT
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
199 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 401
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
202 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 401
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
219 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 401
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
232 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 401
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
205 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE CL A 403
|
| source |
: AC3
|
|
|
6)
|
chain |
A |
| residue |
219 |
| type |
SITE |
| sequence |
C
|
| description |
Essential for function
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
232 |
| type |
SITE |
| sequence |
H
|
| description |
Essential for function
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
264 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
A |
| residue |
259 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
A |
| residue |
261 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|