eF-site ID 2g2f-B PDB Code 2g2f Chain B click to enlarge Title A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain Classification TRANSFERASE Compound Abl Kinase Source Homo sapiens (Human) (2G2F) Sequence B:  KWEMERTDITMKHKLGEVYEGVWKKYSLTVAVKTLKEDTM EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFM TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAPAG AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMS PYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQW NPSDRPSFAEIHQAFETMFQESSI Description Functional site 1) chain B residue 248 type sequence L description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 2) chain B residue 256 type sequence V description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 3) chain B residue 269 type sequence A description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 4) chain B residue 315 type sequence T description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 5) chain B residue 316 type sequence E description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 6) chain B residue 317 type sequence F description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 7) chain B residue 318 type sequence M description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 8) chain B residue 321 type sequence G description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 9) chain B residue 322 type sequence N description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 10) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE AGS B 601 source : AC1 11) chain B residue 446 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P00520 source Swiss-Prot : SWS_FT_FI6 12) chain B residue 393 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 source Swiss-Prot : SWS_FT_FI5 13) chain B residue 363 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 248 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 15) chain B residue 271 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 16) chain B residue 316 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 17) chain B residue 257 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 413 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links