eF-site ID 2g20-B PDB Code 2g20 Chain B click to enlarge Title Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring Classification HYDROLASE Compound Renin Source null (RENI_HUMAN) Sequence B:  SSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVP SSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGT VSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGV VGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSE NSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALG AKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQ ESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEF DRRNNRIGFALAR Description (1)  Renin (E.C.3.4.23.15) Functional site 1) chain B residue 14 type sequence Q description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 2) chain B residue 33 type sequence D description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 3) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 4) chain B residue 78 type sequence Y description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 5) chain B residue 79 type sequence S description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 6) chain B residue 80 type sequence T description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 7) chain B residue 113 type sequence P description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 8) chain B residue 116 type sequence L description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 9) chain B residue 117 type sequence A description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 10) chain B residue 119 type sequence F description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 11) chain B residue 221 type sequence D description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 12) chain B residue 223 type sequence G description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 13) chain B residue 224 type sequence A description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 14) chain B residue 225 type sequence S description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 15) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 16) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 17) chain B residue 298 type sequence M description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 18) chain B residue 309 type sequence A description BINDING SITE FOR RESIDUE L1A B 886 source : AC2 19) chain B residue 33 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 221 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 70 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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