eF-site ID 2g20-A PDB Code 2g20 Chain A click to enlarge Title Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring Classification HYDROLASE Compound Renin Source Homo sapiens (Human) (RENI_HUMAN) Sequence A:  SSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVP SSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGT VSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGV VGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSE NSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKG VSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALG AKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQ ESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEF DRRNNRIGFALAR Description (1)  Renin (E.C.3.4.23.15) Functional site 1) chain A residue 14 type sequence Q description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 2) chain A residue 33 type sequence D description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 3) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 4) chain A residue 55 type sequence Y description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 5) chain A residue 78 type sequence Y description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 6) chain A residue 79 type sequence S description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 7) chain A residue 80 type sequence T description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 8) chain A residue 113 type sequence P description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 9) chain A residue 116 type sequence L description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 10) chain A residue 117 type sequence A description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 11) chain A residue 119 type sequence F description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 12) chain A residue 221 type sequence D description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 13) chain A residue 223 type sequence G description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 14) chain A residue 224 type sequence A description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 15) chain A residue 225 type sequence S description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 16) chain A residue 226 type sequence Y description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 17) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 18) chain A residue 296 type sequence H description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 19) chain A residue 298 type sequence M description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 20) chain A residue 300 type sequence I description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 21) chain A residue 309 type sequence A description BINDING SITE FOR RESIDUE L1A A 885 source : AC1 22) chain A residue 33 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 221 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 70 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 30-41 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 26) chain A residue 218-229 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141

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