eF-site ID 2g06-AB PDB Code 2g06 Chain A, B click to enlarge Title X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, with bound magnesium(II) Classification HYDROLASE Compound Cytosolic 5'-nucleotidase III Source Mus musculus (Mouse) (5NT3_MOUSE) Sequence A:  AVHLKXXPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQI ITDFDXTLSRFSYNGKRCPTCHNIIDNCKLVTDECRRKLL QLKEQYYAIEVDPVLTVEEKFPYXVEWYTKSHGLLIEQGI PKAKLKEIVADSDVXLKEGYENFFGKLQQHGIPVFIFSAG IGDVLEEVIRQAGVYHSNVKVVSNFXDFDENGVLKGFKGE LIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGDLRXA DGVANVEHILKIGYLNDRVDELLEKYXDSYDIVLVKEESL EVVNSILQKTL B:  AVHLKXXPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQI ITDFDXTLSRFSYNGKRCPTCHNIIDNCKLVTDECRRKLL QLKEQYYAIEVDPVLTVEEKFPYXVEWYTKSHGLLIEQGI PKAKLKEIVADSDVXLKEGYENFFGKLQQHGIPVFIFSAG IGDVLEEVIRQAGVYHSNVKVVSNFXDFDENGVLKGFKGE LIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGDLRXA DGVANVEHILKIGYLNDRVDELLEKYXDSYDIVLVKEESL EVVNSILQKTL Description Functional site 1) chain A residue 49 type sequence D description BINDING SITE FOR RESIDUE MG A 900 source : AC1 2) chain A residue 51 type sequence D description BINDING SITE FOR RESIDUE MG A 900 source : AC1 3) chain A residue 238 type sequence D description BINDING SITE FOR RESIDUE MG A 900 source : AC1 4) chain B residue 49 type sequence D description BINDING SITE FOR RESIDUE MG B 901 source : AC2 5) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE MG B 901 source : AC2 6) chain B residue 238 type sequence D description BINDING SITE FOR RESIDUE MG B 901 source : AC2 7) chain A residue 294 type sequence Q description BINDING SITE FOR RESIDUE PIN A 1001 source : AC3 8) chain A residue 295 type sequence K description BINDING SITE FOR RESIDUE PIN A 1001 source : AC3 9) chain A residue 297 type sequence L description BINDING SITE FOR RESIDUE PIN A 1001 source : AC3 10) chain B residue 294 type sequence Q description BINDING SITE FOR RESIDUE PIN B 1002 source : AC4 11) chain B residue 295 type sequence K description BINDING SITE FOR RESIDUE PIN B 1002 source : AC4 12) chain B residue 297 type sequence L description BINDING SITE FOR RESIDUE PIN B 1002 source : AC4 13) chain A residue 49 type ACT_SITE sequence D description Nucleophile => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 49 type ACT_SITE sequence D description Nucleophile => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 51 type ACT_SITE sequence D description Proton donor => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 51 type ACT_SITE sequence D description Proton donor => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 49 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 238 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 51 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 164 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 213 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 238 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 49 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 51 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 164 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 26) chain B residue 213 type BINDING sequence K description BINDING => ECO:0000269|PubMed:16672222 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 96 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9W197 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 117 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9W197 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 96 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q9W197 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 117 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9W197 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 239 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI5 32) chain B residue 239 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21183079 source Swiss-Prot : SWS_FT_FI5

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