eF-site ID 2g01-A PDB Code 2g01 Chain A click to enlarge Title Pyrazoloquinolones as Novel, Selective JNK1 inhibitors Classification TRANSFERASE Compound Mitogen-activated protein kinase 8 Source null (JIP1_HUMAN) Sequence A:  FYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILE RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLL NVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMS YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILD FGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDLW SVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFM KKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKL KASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSE AEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEH Description Functional site 1) chain A residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 2) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 3) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 4) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 5) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 6) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC2 7) chain A residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 B 701 source : AC3 8) chain A residue 32 type sequence I description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 9) chain A residue 53 type sequence A description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 10) chain A residue 108 type sequence M description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 11) chain A residue 111 type sequence M description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 12) chain A residue 113 type sequence A description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 13) chain A residue 114 type sequence N description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 14) chain A residue 168 type sequence L description BINDING SITE FOR RESIDUE 73Q A 901 source : AC5 15) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 16) chain A residue 61-163 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDC description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351 17) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 183 type MOD_RES sequence E description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 185 type MOD_RES sequence E description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5

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