eF-site ID 2fvj-A PDB Code 2fvj Chain A click to enlarge Title A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro Classification SIGNALING PROTEIN Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (NCOA1_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKKEVAIRIFQGCQFRSVEAVQEITEY AKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGV LISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALEL DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALEL QLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT ETDMSLHPLLQEIYKDLY Description Functional site 1) chain A residue 226 type sequence F description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 2) chain A residue 228 type sequence L description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 3) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 4) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 5) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 6) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 7) chain A residue 295 type sequence E description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 8) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 9) chain A residue 329 type sequence M description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 10) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 11) chain A residue 339 type sequence V description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 12) chain A residue 340 type sequence L description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 13) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 14) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 15) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 16) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE RO0 A 501 source : AC1 17) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 18) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 19) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 20) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 21) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 22) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 23) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE GOL A 601 source : AC2 24) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 25) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 26) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 27) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 28) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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