eF-site ID 2fuu_10-A
PDB Code 2fuu
Model 10
Chain A

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Title NMR solution structure of the PHD domain from the human BPTF in complex with H3(1-15)K4me3 peptide
Classification PROTEIN BINDING
Compound bromodomain PHD finger transcription factor
Source Zygosaccharomyces bailii (H3_ZYGBA)
Sequence A:  GPLGSDTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGI
LQSEAELIDEYVCPQCQSTEDA
Description


Functional site

1) chain A
residue 26
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

2) chain A
residue 27
type
sequence D
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

3) chain A
residue 28
type
sequence R
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

4) chain A
residue 29
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

5) chain A
residue 52
type
sequence V
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

6) chain A
residue 53
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

7) chain A
residue 56
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 201
source : AC1

8) chain A
residue 11
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 202
source : AC2

9) chain A
residue 13
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 202
source : AC2

10) chain A
residue 34
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 202
source : AC2

11) chain A
residue 37
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 202
source : AC2

12) chain A
residue 11-26
type prosite
sequence CICKTPYDESKFYIGC
description EGF_2 EGF-like domain signature 2. CiCktPYdeskfyigC
source prosite : PS01186

13) chain A
residue 11-56
type prosite
sequence CICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDE
YVCPQC
description ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpydeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC
source prosite : PS01359

14) chain A
residue 10
type SITE
sequence Y
description Histone H3K4me3 binding
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 17
type SITE
sequence Y
description Histone H3K4me3 binding
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 23
type SITE
sequence Y
description Histone H3K4me3 binding
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 32
type SITE
sequence W
description Histone H3K4me3 binding
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 8-59
type ZN_FING
sequence KLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAEL
IDEYVCPQCQST
description PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146
source Swiss-Prot : SWS_FT_FI1


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