eF-site ID 2fnt-B PDB Code 2fnt Chain B click to enlarge Title Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate. Classification HYDROLASE Compound protease Source (2FNT) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 68 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 2) chain B residue 69 type sequence H description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 3) chain B residue 70 type sequence K description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 4) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 5) chain B residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 6) chain B residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 7) chain B residue 87 type sequence R description BINDING SITE FOR RESIDUE ACT A 504 source : AC3 8) chain B residue 91 type sequence T description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 9) chain B residue 94 type sequence G description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 10) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 11) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 12) chain B residue 19 type sequence L description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 13) chain B residue 44 type sequence P description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 14) chain B residue 45 type sequence K description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 15) chain B residue 46 type sequence M description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 16) chain B residue 7 type sequence K description BINDING SITE FOR RESIDUE ACT B 509 source : AC8 17) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE ACT B 509 source : AC8 18) chain B residue 61 type sequence Q description BINDING SITE FOR RESIDUE ACT A 510 source : AC9 19) chain B residue 25 type ACT_SITE sequence N description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links