eF-site ID 2fnt-ABP PDB Code 2fnt Chain A, B, P click to enlarge Title Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate. Classification HYDROLASE Compound protease Source (2FNT) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF B:  PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PANIIGRNLLTQIGCTLNF P:  RQVNFLG Description Functional site 1) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 2) chain B residue 68 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 3) chain B residue 69 type sequence H description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 4) chain B residue 70 type sequence K description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 5) chain B residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 6) chain B residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 7) chain B residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 B 502 source : AC2 8) chain A residue 7 type sequence K description BINDING SITE FOR RESIDUE ACT A 504 source : AC3 9) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE ACT A 504 source : AC3 10) chain B residue 87 type sequence R description BINDING SITE FOR RESIDUE ACT A 504 source : AC3 11) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 12) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 13) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 14) chain A residue 6 type sequence W description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 15) chain A residue 51 type sequence G description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 16) chain B residue 91 type sequence T description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 17) chain B residue 94 type sequence G description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 18) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 19) chain A residue 63 type sequence P description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 20) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 21) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 A 507 source : AC6 22) chain B residue 19 type sequence L description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 23) chain B residue 44 type sequence P description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 24) chain B residue 45 type sequence K description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 25) chain B residue 46 type sequence M description BINDING SITE FOR RESIDUE PO4 B 508 source : AC7 26) chain B residue 7 type sequence K description BINDING SITE FOR RESIDUE ACT B 509 source : AC8 27) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE ACT B 509 source : AC8 28) chain A residue 58 type sequence Q description BINDING SITE FOR RESIDUE ACT A 510 source : AC9 29) chain B residue 61 type sequence Q description BINDING SITE FOR RESIDUE ACT A 510 source : AC9 30) chain A residue 25 type ACT_SITE sequence N description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 25 type ACT_SITE sequence N description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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