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eF-site ID
|
2flp-APT |
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PDB Code
|
2flp |
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Chain
|
A, P, T |
|
click to enlarge
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Title
|
Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) |
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Classification
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REPLICATION/DNA |
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Compound
|
DNA template strand |
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Source
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Homo sapiens (Human) (2FLP) |
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Sequence
|
A: |
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVT
CNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREM
SYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQS
DELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMRE
AMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFS
PKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEE
DSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLI
IRRYYGRESRQCPIPSHVIQVMTPMVDILMKLFRNMTLLS
VCFCNLK
|
| P: |
AGGACCX
|
| T: |
TGGGGTCCT
|
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Description
|
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Functional site
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|
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1)
|
chain |
A |
| residue |
152 |
| type |
ACT_SITE |
| sequence |
T
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
59 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
A |
| residue |
60 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
151 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
64 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
A |
| residue |
96 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
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