eF-site ID 2fl2-AB PDB Code 2fl2 Chain A, B click to enlarge Title crystal structure of KSP in complex with inhibitor 19 Classification CELL CYCLE Compound Kinesin-like protein KIF11 Source null (KIF11_HUMAN) Sequence A:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK IGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYR ESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEY AHRAKNILNK B:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK IGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYR ESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEY AHRAKNILNK Description Functional site 1) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE MG B 602 source : AC1 2) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 603 source : AC2 3) chain A residue 232 type sequence S description BINDING SITE FOR RESIDUE MG A 603 source : AC2 4) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 5) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 6) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 7) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 8) chain A residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 9) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 10) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 11) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 12) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 13) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 14) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 15) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 16) chain B residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 17) chain B residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 18) chain B residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 19) chain B residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 20) chain B residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 21) chain B residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 22) chain B residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 23) chain B residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 24) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 25) chain B residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 26) chain B residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 27) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP B 600 source : AC4 28) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 29) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 30) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 31) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 32) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 33) chain A residue 136 type sequence I description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 34) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 35) chain A residue 160 type sequence L description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 36) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 37) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 38) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 39) chain A residue 217 type sequence G description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 40) chain A residue 218 type sequence A description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 41) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 42) chain A residue 239 type sequence F description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 43) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 44) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 45) chain B residue 118 type sequence E description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 46) chain B residue 119 type sequence R description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 47) chain B residue 133 type sequence A description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 48) chain B residue 136 type sequence I description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 49) chain B residue 137 type sequence P description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 50) chain B residue 160 type sequence L description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 51) chain B residue 211 type sequence Y description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 52) chain B residue 214 type sequence L description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 53) chain B residue 215 type sequence E description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 54) chain B residue 217 type sequence G description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 55) chain B residue 218 type sequence A description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 56) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 57) chain B residue 239 type sequence F description BINDING SITE FOR RESIDUE N4T B 605 source : AC6 58) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 59) chain B residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 60) chain B residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 62) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411

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