eF-site ID 2fl2-A PDB Code 2fl2 Chain A click to enlarge Title crystal structure of KSP in complex with inhibitor 19 Classification CELL CYCLE Compound Kinesin-like protein KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence A:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK IGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYR ESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEY AHRAKNILNK Description Functional site 1) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE MG A 603 source : AC2 2) chain A residue 232 type sequence S description BINDING SITE FOR RESIDUE MG A 603 source : AC2 3) chain A residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 4) chain A residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 5) chain A residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 6) chain A residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 7) chain A residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 8) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 9) chain A residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 10) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 11) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 12) chain A residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 13) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 14) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP A 601 source : AC3 15) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 16) chain A residue 117 type sequence G description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 17) chain A residue 118 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 18) chain A residue 119 type sequence R description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 19) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 20) chain A residue 136 type sequence I description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 21) chain A residue 137 type sequence P description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 22) chain A residue 160 type sequence L description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 23) chain A residue 211 type sequence Y description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 24) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 25) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 26) chain A residue 217 type sequence G description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 27) chain A residue 218 type sequence A description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 28) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 29) chain A residue 239 type sequence F description BINDING SITE FOR RESIDUE N4T A 604 source : AC5 30) chain A residue 259-270 type prosite sequence GKLNLVDLAGSE description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE source prosite : PS00411 31) chain A residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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