eF-site ID 2fl2-A
PDB Code 2fl2
Chain A

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Title crystal structure of KSP in complex with inhibitor 19
Classification CELL CYCLE
Compound Kinesin-like protein KIF11
Source Homo sapiens (Human) (KIF11_HUMAN)
Sequence A:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL
ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY
NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP
RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD
VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG
AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVK
IGKLNLVDLAGSENNINQSLLTLGRVITALVERTPHVPYR
ESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEY
AHRAKNILNK
Description


Functional site

1) chain A
residue 112
type
sequence T
description BINDING SITE FOR RESIDUE MG A 603
source : AC2

2) chain A
residue 232
type
sequence S
description BINDING SITE FOR RESIDUE MG A 603
source : AC2

3) chain A
residue 24
type
sequence R
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

4) chain A
residue 26
type
sequence R
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

5) chain A
residue 27
type
sequence P
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

6) chain A
residue 106
type
sequence Q
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

7) chain A
residue 107
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

8) chain A
residue 108
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

9) chain A
residue 109
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

10) chain A
residue 110
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

11) chain A
residue 111
type
sequence K
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

12) chain A
residue 112
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

13) chain A
residue 113
type
sequence F
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

14) chain A
residue 118
type
sequence E
description BINDING SITE FOR RESIDUE ADP A 601
source : AC3

15) chain A
residue 116
type
sequence E
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

16) chain A
residue 117
type
sequence G
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

17) chain A
residue 118
type
sequence E
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

18) chain A
residue 119
type
sequence R
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

19) chain A
residue 133
type
sequence A
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

20) chain A
residue 136
type
sequence I
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

21) chain A
residue 137
type
sequence P
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

22) chain A
residue 160
type
sequence L
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

23) chain A
residue 211
type
sequence Y
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

24) chain A
residue 214
type
sequence L
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

25) chain A
residue 215
type
sequence E
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

26) chain A
residue 217
type
sequence G
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

27) chain A
residue 218
type
sequence A
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

28) chain A
residue 221
type
sequence R
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

29) chain A
residue 239
type
sequence F
description BINDING SITE FOR RESIDUE N4T A 604
source : AC5

30) chain A
residue 259-270
type prosite
sequence GKLNLVDLAGSE
description KINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE
source prosite : PS00411

31) chain A
residue 105
type BINDING
sequence G
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283
source Swiss-Prot : SWS_FT_FI1

32) chain A
residue 146
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI2


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