eF-site ID 2fi5-EI PDB Code 2fi5 Chain E, I click to enlarge Title Crystal structure of a BPTI variant (Cys38->Ser) in complex with trypsin Classification hydrolase/hydrolase inhibitor Compound Cationic trypsin Source (BPT1_BOVIN) Sequence E:  IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAH CYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT LNNDIMLIKLKSAASLXSRVASISLPTSCASAGTQCLISG WGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNM FCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK NKPGVYTKVCNYVSWIKQTIASN I:  RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGSRA KRNNFKSAEDCMRTCGGA Description Functional site 1) chain E residue 71 type sequence D description BINDING SITE FOR RESIDUE NA E 2001 source : AC1 2) chain E residue 77 type sequence E description BINDING SITE FOR RESIDUE NA E 2001 source : AC1 3) chain E residue 70 type sequence E description BINDING SITE FOR RESIDUE CA E 2002 source : AC2 4) chain E residue 72 type sequence N description BINDING SITE FOR RESIDUE CA E 2002 source : AC2 5) chain E residue 75 type sequence V description BINDING SITE FOR RESIDUE CA E 2002 source : AC2 6) chain E residue 80 type sequence E description BINDING SITE FOR RESIDUE CA E 2002 source : AC2 7) chain E residue 169 type sequence K description BINDING SITE FOR RESIDUE SO4 E 2009 source : AC3 8) chain E residue 173 type sequence P description BINDING SITE FOR RESIDUE SO4 E 2009 source : AC3 9) chain E residue 174 type sequence G description BINDING SITE FOR RESIDUE SO4 E 2009 source : AC3 10) chain E residue 60 type sequence K description BINDING SITE FOR RESIDUE SO4 E 2011 source : AC4 11) chain E residue 61 type sequence S description BINDING SITE FOR RESIDUE SO4 E 2011 source : AC4 12) chain I residue 46 type sequence K description BINDING SITE FOR RESIDUE SO4 E 2011 source : AC4 13) chain I residue 46 type sequence K description BINDING SITE FOR RESIDUE SO4 E 2011 source : AC4 14) chain E residue 97 type sequence N description BINDING SITE FOR RESIDUE EDO E 1001 source : AC5 15) chain E residue 98 type sequence T description BINDING SITE FOR RESIDUE EDO E 1001 source : AC5 16) chain E residue 99 type sequence L description BINDING SITE FOR RESIDUE EDO E 1001 source : AC5 17) chain E residue 175 type sequence Q description BINDING SITE FOR RESIDUE EDO E 1001 source : AC5 18) chain E residue 215 type sequence W description BINDING SITE FOR RESIDUE EDO E 1001 source : AC5 19) chain E residue 153 type sequence D description BINDING SITE FOR RESIDUE EDO E 1002 source : AC6 20) chain E residue 154 type sequence V description BINDING SITE FOR RESIDUE EDO E 1002 source : AC6 21) chain E residue 156 type sequence K description BINDING SITE FOR RESIDUE EDO E 1002 source : AC6 22) chain E residue 95 type sequence N description BINDING SITE FOR RESIDUE EDO E 1003 source : AC7 23) chain E residue 98 type sequence T description BINDING SITE FOR RESIDUE EDO E 1003 source : AC7 24) chain E residue 100 type sequence N description BINDING SITE FOR RESIDUE EDO E 1003 source : AC7 25) chain E residue 129 type sequence A description BINDING SITE FOR RESIDUE EDO E 1004 source : AC8 26) chain E residue 162 type sequence I description BINDING SITE FOR RESIDUE EDO E 1004 source : AC8 27) chain E residue 181 type sequence F description BINDING SITE FOR RESIDUE EDO E 1004 source : AC8 28) chain E residue 210 type sequence Q description BINDING SITE FOR RESIDUE EDO E 1004 source : AC8 29) chain E residue 230 type sequence K description BINDING SITE FOR RESIDUE EDO E 1004 source : AC8 30) chain E residue 20 type sequence Y description BINDING SITE FOR RESIDUE EDO E 1005 source : AC9 31) chain E residue 22 type sequence C description BINDING SITE FOR RESIDUE EDO E 1005 source : AC9 32) chain E residue 26 type sequence T description BINDING SITE FOR RESIDUE EDO E 1005 source : AC9 33) chain E residue 112 type sequence A description BINDING SITE FOR RESIDUE EDO E 1006 source : BC1 34) chain E residue 113 type sequence S description BINDING SITE FOR RESIDUE EDO E 1006 source : BC1 35) chain E residue 114 type sequence L description BINDING SITE FOR RESIDUE EDO E 1006 source : BC1 36) chain E residue 47 type sequence I description BINDING SITE FOR RESIDUE EDO E 1007 source : BC2 37) chain E residue 48 type sequence N description BINDING SITE FOR RESIDUE EDO E 1007 source : BC2 38) chain E residue 239 type sequence K description BINDING SITE FOR RESIDUE EDO E 1007 source : BC2 39) chain E residue 242 type sequence I description BINDING SITE FOR RESIDUE EDO E 1007 source : BC2 40) chain I residue 31 type sequence Q description BINDING SITE FOR RESIDUE CA I 2003 source : BC3 41) chain I residue 31 type sequence Q description BINDING SITE FOR RESIDUE CA I 2003 source : BC3 42) chain I residue 32 type sequence T description BINDING SITE FOR RESIDUE CA I 2003 source : BC3 43) chain I residue 32 type sequence T description BINDING SITE FOR RESIDUE CA I 2003 source : BC3 44) chain I residue 7 type sequence E description BINDING SITE FOR RESIDUE SO4 I 2004 source : BC4 45) chain I residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2004 source : BC4 46) chain I residue 20 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2005 source : BC5 47) chain I residue 35 type sequence Y description BINDING SITE FOR RESIDUE SO4 I 2005 source : BC5 48) chain I residue 37 type sequence G description BINDING SITE FOR RESIDUE SO4 I 2005 source : BC5 49) chain I residue 40 type sequence A description BINDING SITE FOR RESIDUE SO4 I 2005 source : BC5 50) chain E residue 87 type sequence K description BINDING SITE FOR RESIDUE SO4 I 2006 source : BC6 51) chain E residue 107 type sequence K description BINDING SITE FOR RESIDUE SO4 I 2006 source : BC6 52) chain I residue 1 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2006 source : BC6 53) chain I residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2006 source : BC6 54) chain I residue 9 type sequence P description BINDING SITE FOR RESIDUE SO4 I 2007 source : BC7 55) chain I residue 10 type sequence Y description BINDING SITE FOR RESIDUE SO4 I 2007 source : BC7 56) chain I residue 11 type sequence T description BINDING SITE FOR RESIDUE SO4 I 2007 source : BC7 57) chain I residue 12 type sequence G description BINDING SITE FOR RESIDUE SO4 I 2007 source : BC7 58) chain E residue 109 type sequence K description BINDING SITE FOR RESIDUE SO4 I 2008 source : BC8 59) chain E residue 110 type sequence S description BINDING SITE FOR RESIDUE SO4 I 2008 source : BC8 60) chain E residue 111 type sequence A description BINDING SITE FOR RESIDUE SO4 I 2008 source : BC8 61) chain I residue 1 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2008 source : BC8 62) chain E residue 50 type sequence Q description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 63) chain E residue 107 type sequence K description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 64) chain E residue 164 type sequence S description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 65) chain E residue 165 type sequence D description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 66) chain E residue 166 type sequence S description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 67) chain I residue 1 type sequence R description BINDING SITE FOR RESIDUE SO4 I 2010 source : BC9 68) chain E residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 69) chain E residue 189-200 type prosite sequence DSCQGDSGGPVV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV source prosite : PS00135 70) chain I residue 15 type SITE sequence K description Reactive bond for trypsin source Swiss-Prot : SWS_FT_FI1 71) chain E residue 105 type SITE sequence L description Reactive bond for trypsin source Swiss-Prot : SWS_FT_FI1 72) chain E residue 198 type SITE sequence P description Reactive bond for trypsin source Swiss-Prot : SWS_FT_FI1 73) chain E residue 73 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 74) chain E residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 75) chain E residue 78 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 76) chain E residue 83 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 77) chain E residue 192 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 78) chain E residue 195 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 79) chain E residue 198 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI2

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