|
|
eF-site ID
|
2fhh-Y |
|
PDB Code
|
2fhh |
|
Chain
|
Y |
|
click to enlarge
|
|
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Title
|
Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 |
|
Classification
|
HYDROLASE |
|
Compound
|
20S proteasome, alpha and beta subunits |
|
Source
|
(AAK46453) |
|
|
Sequence
|
Y: |
SPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPS
RSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGY
AYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEV
AHYGETKRPELYRITYDGSIADEPHFVVMGGTTEPIANAL
KESYAENASLTDALRIAVAALRAGSLGVASLEVAVLDANR
PRRAFRRITGSALQALLVDQ
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
Y |
| residue |
84 |
| type |
SITE |
| sequence |
T
|
| description |
Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
Y |
| residue |
178 |
| type |
SITE |
| sequence |
T
|
| description |
Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|