eF-site ID 2fhh-T
PDB Code 2fhh
Chain T

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Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273
Classification HYDROLASE
Compound 20S proteasome, alpha and beta subunits
Source (AAK46453)
Sequence T:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY
TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI
NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI
VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG
DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD
GAVDVPESRIAELARAIIESRS
Description


Functional site

1) chain T
residue 301
type
sequence T
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

2) chain T
residue 321
type
sequence T
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

3) chain T
residue 322
type
sequence Q
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

4) chain T
residue 327
type
sequence S
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

5) chain T
residue 346
type
sequence A
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

6) chain T
residue 347
type
sequence G
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

7) chain T
residue 348
type
sequence T
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

8) chain T
residue 349
type
sequence A
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

9) chain T
residue 352
type
sequence A
description BINDING SITE FOR RESIDUE M1N T 273
source : BC1

10) chain T
residue 424
type
sequence D
description BINDING SITE FOR RESIDUE M1N 2 273
source : BC5

11) chain T
residue 301
type ACT_SITE
sequence T
description Nucleophile => ECO:0000305|PubMed:20711362
source Swiss-Prot : SWS_FT_FI1

12) chain T
residue 301
type SITE
sequence T
description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986
source Swiss-Prot : SWS_FT_FI2


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