eF-site ID 2fhh-T PDB Code 2fhh Chain T click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence T:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain T residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 2) chain T residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 3) chain T residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 4) chain T residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 5) chain T residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 6) chain T residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 7) chain T residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 8) chain T residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 9) chain T residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N T 273 source : BC1 10) chain T residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N 2 273 source : BC5 11) chain T residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 12) chain T residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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