eF-site ID 2fhh-R PDB Code 2fhh Chain R click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence R:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain R residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 2) chain R residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 3) chain R residue 320 type sequence S description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 4) chain R residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 5) chain R residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 6) chain R residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 7) chain R residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 8) chain R residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 9) chain R residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 10) chain R residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N R 273 source : AC9 11) chain R residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 12) chain R residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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