eF-site ID 2fhh-P PDB Code 2fhh Chain P click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence P:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain P residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 2) chain P residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 3) chain P residue 320 type sequence S description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 4) chain P residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 5) chain P residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 6) chain P residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 7) chain P residue 333 type sequence K description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 8) chain P residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 9) chain P residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 10) chain P residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 11) chain P residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 12) chain P residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N P 273 source : AC8 13) chain P residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 14) chain P residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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