eF-site ID 2fhh-N PDB Code 2fhh Chain N click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence N:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain N residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N G 273 source : AC4 2) chain N residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 3) chain N residue 320 type sequence S description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 4) chain N residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 5) chain N residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 6) chain N residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 7) chain N residue 345 type sequence I description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 8) chain N residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 9) chain N residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 10) chain N residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 11) chain N residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 12) chain N residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N N 273 source : AC7 13) chain N residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 14) chain N residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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