eF-site ID 2fhh-H PDB Code 2fhh Chain H click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence H:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain H residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 2) chain H residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 3) chain H residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 4) chain H residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 5) chain H residue 331 type sequence V description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 6) chain H residue 333 type sequence K description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 7) chain H residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 8) chain H residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 9) chain H residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 10) chain H residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 11) chain H residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N H 273 source : AC1 12) chain H residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 13) chain H residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 14) chain H residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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